diff --git a/gradle.properties b/gradle.properties
index 28f5f3cba4..2dd52ce211 100644
--- a/gradle.properties
+++ b/gradle.properties
@@ -180,7 +180,7 @@ hadoopHdfsClientVersion=3.4.1
 hamcrestVersion=2.2
 
 # Note: if changing this, we might need to match with the picard version in the SequenceAnalysis module build.gradle
-htsjdkVersion=4.0.0
+htsjdkVersion=4.3.0
 
 httpclient5Version=5.4.3
 httpcore5Version=5.3.4