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@@ -102,6 +102,11 @@ Form the famous movie #link("https://en.wikipedia.org/wiki/Rebel_Without_a_Cause
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The special issue Volume 8, Issue 2, 2022
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Issue of #emph("Observational Studies") titleed #link("https://en.wikipedia.org/wiki/Rebel_with_a_Cause_(book)")[`Rebel With a Cause`]
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== Words
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#quote("Nonparametric identification and estimation of the ATE with non-binary IVs are more involved.") in @dong2025marginal. #emph("involved") means complicated, difficult, complex.
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== Fun example
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=== On overparameterized models
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- The lower bound and upper bound is not a differentiable functional, thus an assumption is invoked to make the bound functional differentiable and thus have inference function to faster convergence rate.
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@dong2025marginal
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- talk about the indenfication of ATE with continuous or multiple-category IVs with binary treatment.
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- data are $(X,D,Z,Y)$
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#image("media/image.png")
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- The identification assumption:
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+ Stable Unit Treatment Value Assumption (SUTVA) for potential outcomes:
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- Consistency and no interference between units:
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$ Y = Y (D) & = D Y(1) + (1-D) Y(0) \
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D & = D(Z) $
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+ [IV relevance (version 1): $ Z cancel(perp) D | X$ almost surely. ]
As @levis2025covariate mentioned, under these assumptions, the ATE is not point identified, homogeneity assumptions are :
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+ Version 1, for binary $Z$ : Either $EE[D | Z = 1, X , U] - EE[D | Z = 0, X , U] $ or $EE[ Y(1) - Y(0) | X , U] $ does not depend on $U$.
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- #quote("Assumption 5′ rules out additive effect modification by U of the Z-D relationship or d-Y (d) relationship within levels of X. A weaker alternative is the no unmeasured common effect modifier assumption (Cui and Tchetgen Tchetgen, 2021, Hartwig et al., 2023), which stipulates that no unmeasured confounder acts as a common effect modifier of both the additive effect of the IV on the treatment and the additive treatment effect on the outcome:")
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+ Version 2, for binary $Z$, following equation holds almost surely:
- The real-data applicationis combine many genetic variants as weak IVs to a strong and continuous IV to solve the "obesity paradox" in oncology.
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- #quote("Obesity is typically associated with poorer oncology outcomes. Paradoxically, however, many observational studies have reported that non-small cell lung cancer (NSCLC) patients with higher body mass index (BMI) experience lower mortality, a phenomenon often referred to as the “obesity paradox” (Zhang et al., 2017).")
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- Using the ratio of conditional weighted average treatment effect, for multiple-category(CWATE) or conditional weighted average derivative effect (CWADE) to identify the ATE.
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- Using semiparametric theory to provide the efficient influence function and build a triply robust estimator.
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- The tangent space is strange such that second-order parametric submodels are needed to validate the efficient influence function.
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@chen2025identification
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== The equivalence between DAG and potential outcome framework
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@@ -283,6 +326,11 @@ Formulation in @van1991differentiable
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- Peregrine @jamshidi2020peregrine
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- Automine @mawhirter2019automine
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== Occurrence
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=== Energy function in N particle system
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The interaction energy function in N particle system can be written as a U statistic.
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