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As @levis2025covariate mentioned, under these assumptions, the ATE is not point identified, homogeneity assumptions are :
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+ Version 1, for binary $Z$ : Either $EE[D | Z = 1, X , U] - EE[D | Z = 0, X , U] $ or $EE[ Y(1) - Y(0) | X , U] $ does not depend on $U$.
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- #quote("Assumption 5′ rules out additive effect modification by U of the Z-D relationship or d-Y (d) relationship within levels of X. A weaker alternative is the no unmeasured common effect modifier assumption (Cui and Tchetgen Tchetgen, 2021, Hartwig et al., 2023), which stipulates that no unmeasured confounder acts as a common effect modifier of both the additive effect of the IV on the treatment and the additive treatment effect on the outcome:")
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+ Version 2, for binary $Z$, following equation holds almost surely:
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- #quote([Assumption 5′ rules out additive effect modification by $U$ of the $Z-D$ relationship or $d-Y (d)$ relationship within levels of $X$. A weaker alternative is the no unmeasured common effect modifier assumption (Cui and Tchetgen Tchetgen, 2021, Hartwig et al., 2023), which stipulates that no unmeasured confounder acts as a common effect modifier of both the additive effect of the IV on the treatment and the additive treatment effect on the outcome:])
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+ Version 2, weaker alternative for binary $Z$, following equation holds almost surely:
@@ -265,7 +265,7 @@ As @levis2025covariate mentioned, under these assumptions, the ATE is not point
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- The real-data applicationis combine many genetic variants as weak IVs to a strong and continuous IV to solve the "obesity paradox" in oncology.
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- #quote("Obesity is typically associated with poorer oncology outcomes. Paradoxically, however, many observational studies have reported that non-small cell lung cancer (NSCLC) patients with higher body mass index (BMI) experience lower mortality, a phenomenon often referred to as the “obesity paradox” (Zhang et al., 2017).")
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- Using the ratio of conditional weighted average treatment effect, for multiple-category(CWATE) or conditional weighted average derivative effect (CWADE) to identify the ATE.
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- Using the ratio of conditional weighted average treatment effect, for multiple-category(CWATE) or conditional weighted average derivative effect (CWADE) to identify the ATE.
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- Using semiparametric theory to provide the efficient influence function and build a triply robust estimator.
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