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@@ -247,15 +247,15 @@ Here $serif(Pr)(Y(1) = b | G = g)$ and $serif(Pr)( Y(0) = a | G = g)$ can be ide
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- Consistency and no interference between units:
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$ Y = Y (D) & = D Y(1) + (1-D) Y(0) \
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D & = D(Z) $
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+ [IV relevance (version 1): $ Z cancel(perp) D | X$ almost surely. ]
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+ IV relevance (version 1): $ Z cancel(perp) D | X$ almost surely.
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+ IV independence : $ Z perp U | X$
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+ IV exclusion restriction : $Z perp Y | D, X$
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+ Unconfounderness/d-separation : $ (Z, D) perp Y(d) | X, U$ for $d = 0,1$
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As @levis2025covariate mentioned, under these assumptions, the ATE is not point identified, homogeneity assumptions are :
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+ Version 1, for binary $Z$ : Either $ EE[D | Z = 1, X , U] - EE[D | Z = 0, X , U] $ or $ EE[ Y(1) - Y(0) | X , U] $ does not depend on $U$.
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- #quote("Assumption 5′ rules out additive effect modification by U of the Z-D relationship or d-Y (d) relationship within levels of X. A weaker alternative is the no unmeasured common effect modifier assumption (Cui and Tchetgen Tchetgen, 2021, Hartwig et al., 2023), which stipulates that no unmeasured confounder acts as a common effect modifier of both the additive effect of the IV on the treatment and the additive treatment effect on the outcome:")
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+ Version 2, for binary $Z$, following equation holds almost surely:
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- #quote([Assumption 5′ rules out additive effect modification by $U$ of the $Z-D$ relationship or $d-Y (d)$ relationship within levels of $X$. A weaker alternative is the no unmeasured common effect modifier assumption (Cui and Tchetgen Tchetgen, 2021, Hartwig et al., 2023), which stipulates that no unmeasured confounder acts as a common effect modifier of both the additive effect of the IV on the treatment and the additive treatment effect on the outcome:])
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+ Version 2, weaker alternative for binary $Z$, following equation holds almost surely:
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$ "Cov"(EE(D| Z= 1, X, U)- EE(D|Z=0, X, U), EE(Y(1) - Y(0) | X,U) | X ) = 0 $
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+ Final version, for continuous or multiple-category $Z$, for any $z$ in the support of $Z$, following equation holds almost surely:
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$ "Cov"(EE(D| Z= z, X, U)- EE(D| X, U), EE(Y(1) - Y(0) | X,U) | X ) = 0 $
@@ -265,7 +265,7 @@ As @levis2025covariate mentioned, under these assumptions, the ATE is not point
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- The real-data applicationis combine many genetic variants as weak IVs to a strong and continuous IV to solve the "obesity paradox" in oncology.
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- #quote("Obesity is typically associated with poorer oncology outcomes. Paradoxically, however, many observational studies have reported that non-small cell lung cancer (NSCLC) patients with higher body mass index (BMI) experience lower mortality, a phenomenon often referred to as the “obesity paradox” (Zhang et al., 2017).")
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- Using the ratio of conditional weighted average treatment effect, for multiple-category(CWATE) or conditional weighted average derivative effect (CWADE) to identify the ATE.
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- Using the ratio of conditional weighted average treatment effect, for multiple-category (CWATE) or conditional weighted average derivative effect (CWADE) to identify the ATE.
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- Using semiparametric theory to provide the efficient influence function and build a triply robust estimator.
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static/notes/notes.pdf

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