diff --git a/.github/workflows/pypi.yml b/.github/workflows/pypi.yml
new file mode 100644
index 0000000..21687eb
--- /dev/null
+++ b/.github/workflows/pypi.yml
@@ -0,0 +1,34 @@
+name: pypi
+on: [push]
+jobs:
+  pypi:
+    name: upload to pypi
+    runs-on: ubuntu-latest
+    steps:
+    - uses: actions/checkout@v3
+      with:
+        fetch-depth: 0
+    - name: Set up Python
+      uses: actions/setup-python@v4
+      with:
+        python-version: '3.9'
+    - name: Install build prerequisites
+      if: github.event_name == 'push' && startsWith(github.event.ref, 'refs/tags')
+      run: |
+        python -m pip install --upgrade twine build cibuildwheel
+    - name: sdist
+      if: github.event_name == 'push' && startsWith(github.event.ref, 'refs/tags')
+      run: |
+        python -m build --sdist
+    - name: wheel
+      if: github.event_name == 'push' && startsWith(github.event.ref, 'refs/tags')
+      run: |
+        python -m cibuildwheel --output-dir wheelhouse
+    - name: upload
+      if: github.event_name == 'push' && startsWith(github.event.ref, 'refs/tags')
+      env:
+        TWINE_USERNAME: "__token__"
+        TWINE_PASSWORD: ${{ secrets.pypi_password }}
+      run: |
+        twine upload dist/*
+        twine upload wheelhouse/*
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..ae5db1e
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,41 @@
+[build-system]
+requires = ["setuptools>=42", "setuptools-scm"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "py2bit"
+version = "0.3.3"
+description = "A package for accessing 2bit files using lib2bit"
+authors = [
+    { name = "Devon P. Ryan", email = "dpryan79@gmail.com" }
+]
+license = { text = "MIT" }
+readme = "README.md"
+keywords = ["bioinformatics", "2bit"]
+classifiers = [
+    "Development Status :: 5 - Production/Stable",
+    "Intended Audience :: Developers",
+    "License :: OSI Approved",
+    "Programming Language :: C",
+    "Programming Language :: Python",
+    "Programming Language :: Python :: 2.7",
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: Implementation :: CPython",
+    "Operating System :: POSIX",
+    "Operating System :: Unix",
+    "Operating System :: MacOS"
+]
+
+[project.urls]
+download = "https://github.com/deeptools/py2bit"
+homepage = "https://github.com/deeptools/py2bit"
+
+# Enable version inference from scm
+[tool.setuptools_scm]
+
+# Target only minimum CPython version 3.9 on linux for wheel build
+[tool.cibuildwheel]
+skip = "pp* cp38-* *-manylinux_i686 *_ppc64le *_s390x *-musllinux_x86_64 *-musllinux_i686"
+
+[tool.cibuildwheel.linux]
+manylinux-x86_64-image = "manylinux2014"
diff --git a/setup.py b/setup.py
index 9a3ff17..bc10a0a 100755
--- a/setup.py
+++ b/setup.py
@@ -17,7 +17,7 @@
                     include_dirs = ['lib2bit', sysconfig.get_config_var("INCLUDEPY")])
 
 setup(name = 'py2bit',
-       version = '0.3.2',
+       version = '0.3.3',
        description = 'A package for accessing 2bit files using lib2bit',
        author = "Devon P. Ryan",
        author_email = "dpryan79@gmail.com",