diff --git a/compiler/rustc_parse/src/parser/expr.rs b/compiler/rustc_parse/src/parser/expr.rs
index 35b987cf50fa2..f64537e41cca6 100644
--- a/compiler/rustc_parse/src/parser/expr.rs
+++ b/compiler/rustc_parse/src/parser/expr.rs
@@ -2742,6 +2742,36 @@ impl<'a> Parser<'a> {
         let (mut cond, _) =
             self.parse_expr_res(Restrictions::NO_STRUCT_LITERAL | Restrictions::ALLOW_LET, attrs)?;
 
+        // Support a more natural "let chain" syntax using commas:
+        //
+        //     if let Some(x) = a, let None = b { ... }
+        //
+        // This is parsed as an `&&`-chain in the AST (same as `..., && let ...`), which keeps
+        // semantics unchanged (short-circuiting, temporary lifetimes/drop order) and reuses the
+        // existing let-chain validation and lowering logic.
+        //
+        // We intentionally only treat `, let ...` at the top level of a condition as chain
+        // separators. This avoids ambiguity with tuple expressions and keeps the change local to
+        // `if`/`while` condition parsing.
+        while self.token == token::Comma
+            && self.look_ahead(1, |t| t.is_keyword(kw::Let))
+        {
+            let comma_span = self.token.span;
+            self.bump(); // Eat `,`
+
+            let next_attrs = self.parse_outer_attributes()?;
+            let (next, _) = self.parse_expr_res(
+                Restrictions::NO_STRUCT_LITERAL | Restrictions::ALLOW_LET,
+                next_attrs,
+            )?;
+
+            let span = self.mk_expr_sp(&cond, cond.span, comma_span, next.span);
+            cond = self.mk_expr(
+                span,
+                ExprKind::Binary(Spanned { span: comma_span, node: BinOpKind::And }, cond, next),
+            );
+        }
+
         CondChecker::new(self, let_chains_policy).visit_expr(&mut cond);
 
         Ok(cond)
diff --git a/tests/ui/rfcs/rfc-2497-if-let-chains/comma-let-chains-edition-gate.rs b/tests/ui/rfcs/rfc-2497-if-let-chains/comma-let-chains-edition-gate.rs
new file mode 100644
index 0000000000000..924b315fb8d62
--- /dev/null
+++ b/tests/ui/rfcs/rfc-2497-if-let-chains/comma-let-chains-edition-gate.rs
@@ -0,0 +1,24 @@
+//@ edition: 2021
+
+#![allow(irrefutable_let_patterns)]
+
+fn _if() {
+    if let 0 = 1, let 1 = 2 {}
+    //~^ ERROR let chains are only allowed in Rust 2024 or later
+    //~| ERROR let chains are only allowed in Rust 2024 or later
+
+    if true, let 0 = 1 {}
+    //~^ ERROR let chains are only allowed in Rust 2024 or later
+}
+
+fn _while() {
+    while let 0 = 1, let 1 = 2 {}
+    //~^ ERROR let chains are only allowed in Rust 2024 or later
+    //~| ERROR let chains are only allowed in Rust 2024 or later
+
+    while true, let 0 = 1 {}
+    //~^ ERROR let chains are only allowed in Rust 2024 or later
+}
+
+fn main() {}
+
diff --git a/tests/ui/rfcs/rfc-2497-if-let-chains/comma-let-chains.rs b/tests/ui/rfcs/rfc-2497-if-let-chains/comma-let-chains.rs
new file mode 100644
index 0000000000000..ccf39048f4458
--- /dev/null
+++ b/tests/ui/rfcs/rfc-2497-if-let-chains/comma-let-chains.rs
@@ -0,0 +1,33 @@
+//@ run-pass
+//@ edition: 2024
+
+fn main() {
+    let a = Some(1);
+    let b: Option<i32> = None;
+
+    // Basic: multiple `let` conditions chained with `, let ...`.
+    let mut hit = false;
+    if let Some(x) = a, let None = b {
+        hit = true;
+        assert_eq!(x, 1);
+    }
+    assert!(hit);
+
+    // Short-circuit: the second `let` must not be evaluated if the first fails.
+    let mut side_effect = 0;
+    let c: Option<i32> = None;
+    let d = Some(2);
+    if let Some(_x) = c, let Some(_y) = { side_effect += 1; d } {
+        unreachable!("first `let` fails, so the second must not run");
+    }
+    assert_eq!(side_effect, 0);
+
+    // Mix a boolean with `, let ...` in a `while` condition.
+    let mut counter = 0;
+    while counter < 1, let Some(y) = a {
+        assert_eq!(y, 1);
+        counter += 1;
+    }
+    assert_eq!(counter, 1);
+}
+