Programs in IGV_MacApp_2.19.7_WithJava.zip only have the user executable bit set, not the group/other. So if IGV is installed by root is it not runnable by other users.
-rwxrw-r-- 1 markd staff 136400 2025-10-28 11:45 IGV_2.19.7.app/Contents/MacOS/IGV
All files have these permissions, including ones that are not programs