Drawing a line over large distances with DrawLine, the end will be off. In the example below there is a difference of 39 pixels in height.
Drawing a line with DrawLineAa, the end will be of by 1 in width and height.
WriteableBitmap image = new WriteableBitmap(30000, 10000, 96, 96, PixelFormats.Pbgra32, null);
image.Clear(Colors.White);
image.DrawLine(0, 0, 29999, 9999, Colors.Black);
image.DrawLineAa(0, 0, 29999, 9999, Colors.Red);