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An ion-based model for swelling of neurons and astrocytes (Hubel & Ullah 2016)
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The code files "code_Fig3.ode" and "code_Fig4.ode" were used for the respective simulations of Fig. 3 and 7 in *********************************************************************** Hübel, N. and Ullah, G., "Anions Govern Cell Volume: a Case Study of Relative Astrocytic and Neuronal Swelling in Spreading Depolarization", PLoS ONE, 10.1371/journal.pone.0147060 (2016). *********************************************************************** The code is written for XPP/XPPAUT. Running "code_Fig3.ode" yields the time series shown in the main parts of Fig. 3. Changing "par s=0" to "par s=1" in line 45 (or equivalently changing "s=0" to "s=1" in the parameter settings of the XPP/XPPAUT graphical interface) changes the volume model from "derived" to "exponential" (see manuscript) and yields the time series shown in the insets of Fig. 3. The default plot setting in line 198 shows the potentials. Uncommenting line 199 or 200 will show volumes and ion concentrations, respectively. In addition, by changing "par gcl_l=0.05" to "par gcl_l=0" in line 135 (or setting the parameter "gcl_l" to zero in the parameter interface after opening the file with XPP/XPPAUT) will produce Fig. 4 of the paper. Running "code_Fig7.ode" yields the time series shown in Fig 7. The plot setting in lines 239 (default), 240 and 241 show the potentials volumes and relative volume changes. Note that the volume plot shows absolute volumes as the differences between the "vli_line", the "vle_line" and the "vlg_line".
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