Article:

Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. However, it may still be underappreciated that multiplexing 1000s of samples with mass tags does not actually require 1000s of isotopes, or 1000s of synthesis steps to create. We show in the article that plex sizes in the hundreds, an order of magnitude greater than state-of-the-art, are achievable using molecules comparable in size to existing commercial tags, and that going beyond hundreds may require larger molecules

Code:

This repository contains the scripts used to generate figures for the article.

Media:

Miscellaneous information, including publicly-available presentations about the article are available through: parallelsq.org/tagdesign.